Lieu: Brunoy + visio

RésuméThe neurovascular unit (NVU) is a complex fine tuned microenvironment composed by neuron, astrocyte, endothelium, smooth muscle cell, pericyte and microglia. All these cell types play physiological role in the functional maintenance and the adapted passage of the blood brain barrier (BBB). Any perturbation in this environment will cause major disturbing consequences on the brain function and organ homeostasis. Increasing evidence points to a pathophysiological role of cerebrovascular dysfunction in brain diseases, including traumatic brain injury, stroke as well as neurodegenerative diseases. Changes in the NVU will directly trigger abnormal neuronal activity caused by alterations of the cerebral perfusion and permeability. During the presentation, recent data on blood-brain interface communications and changes from mild injury models will be reviewed from the molecular to behavioral outcomes with a look on neuronal and cerebral blood vessel network. These results will support the following general hypothesis: the occurring events of neurovascular pathophysiology represent a mechanism and a biomarker of long-term neurological sequelae and pathology progress in many brain disorders and their resolution by repair mechanisms.