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Auteur (up) Djelti, F.; Dhenain, M.; Terrien, J.; Picq, J.-L.; Hardy, I.; Champeval, D.; Perret, M.; Schenker, E.; Epelbaum, J.; Aujard, F. url  doi
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  Titre Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates Type Article scientifique
  Année 2016 Publication Aging Revue Abrégée Aging (Albany NY)  
  Volume 9 Numéro 1 Pages 173-186  
  Mots-Clés Microcebus murinus; blood glucose; hippocampal/septal atrophy; middle age; spatial memory performance; spontaneous models  
  Résumé Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper normal range are associated with memory impairment and cerebral atrophy. Due to a close evolutional similarity to Man, non-human primates may be useful to investigate the relationships between glucose homeostasis, cognitive deficits and structural brain alterations. In the grey mouse lemur, Microcebus murinus, spatial memory deficits have been associated with age and cerebral atrophy but the origin of these alterations have not been clearly identified. Herein, we showed that, on 28 female grey mouse lemurs (age range 2.4-6.1 years-old), age correlated with impaired fasting blood glucose (rs=0.37) but not with impaired glucose tolerance or insulin resistance. In middle-aged animals (4.1-6.1 years-old), fasting blood glucose was inversely and closely linked with spatial memory performance (rs=0.56) and hippocampus (rs=-0.62) or septum (rs=-0.55) volumes. These findings corroborate observations in humans and further support the grey mouse lemur as a natural model to unravel mechanisms which link impaired glucose homeostasis, brain atrophy and cognitive processes.  
  Adresse MECADEV UMR 7179, Centre National de la Recherche Scientifique, Museum National d'Histoire Naturelle, 91800 Brunoy, France  
  Auteur institutionnel Thèse  
  Editeur Lieu de Publication Éditeur  
  Langue English Langue du Résumé Titre Original  
  Éditeur de collection Titre de collection Titre de collection Abrégé  
  Volume de collection Numéro de collection Edition  
  ISSN 1945-4589 ISBN Médium  
  Région Expédition Conférence  
  Notes PMID:28039490; PMCID:PMC5310663 Approuvé pas de  
  Numéro d'Appel CNRS @ aujard @ collection 1596  
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