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Auteur (up) Rahman, A.; Lamberty, Y.; Schenker, E.; Cella, M.; Languille, S.; Bordet, R.; Richardson, J.; Pifferi, F.; Aujard, F. url  doi
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  Titre Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus) Type Article scientifique
  Année 2017 Publication PloS one Revue Abrégée PLoS One  
  Volume 12 Numéro 9 Pages e0184822  
  Mots-Clés Aging/*drug effects; Alzheimer Disease/complications/drug therapy/physiopathology; Animals; Cheirogaleidae; Disease Models, Animal; Indans/*pharmacology; Male; Memantine/*pharmacology; Memory Disorders/*drug therapy/etiology/physiopathology; Piperidines/*pharmacology; Sleep Deprivation/complications/*drug therapy/physiopathology; Spatial Memory/*drug effects  
  Résumé The development of novel therapeutics to prevent cognitive decline of Alzheimer's disease (AD) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide marginal therapeutic benefits to AD patients. There is an urgent need to develop a predictive animal model that is phylogenetically proximal to humans to achieve better translation. The non-human primate grey mouse lemur (Microcebus murinus) is increasingly used in aging research, but there is no published results related to the impact of known pharmacological treatments on age-related cognitive impairment observed in this primate. In the present study we investigated the effects of DON and MEM on sleep-deprivation (SD)-induced memory impairment in young and aged male mouse lemurs. In particular, spatial memory impairment was evaluated using a circular platform task after 8 h of total SD. Acute single doses of DON or MEM (0.1 and 1mg/kg) or vehicle were administered intraperitoneally 3 h before the cognitive task during the SD procedure. Results indicated that both doses of DON were able to prevent the SD-induced deficits in retrieval of spatial memory as compared to vehicle-treated animals, both in young and aged animals Likewise, MEM show a similar profile at 1 mg/kg but not at 0.1mg/kg. Taken together, these results indicate that two widely used drugs for mitigating cognitive deficits in AD were partially effective in sleep deprived mouse lemurs, which further support the translational potential of this animal model. Our findings demonstrate the utility of this primate model for further testing cognitive enhancing drugs in development for AD or other neuropsychiatric conditions.  
  Adresse UMR 7179 Centre National de la Recherche Scientifique, Museum National d'Histoire Naturelle, Brunoy, France  
  Auteur institutionnel Thèse  
  Editeur Lieu de Publication Éditeur  
  Langue English Langue du Résumé Titre Original  
  Éditeur de collection Titre de collection Titre de collection Abrégé  
  Volume de collection Numéro de collection Edition  
  ISSN 1932-6203 ISBN Médium  
  Région Expédition Conférence  
  Notes PMID:28922421; PMCID:PMC5602634 Approuvé pas de  
  Numéro d'Appel CNRS @ aujard @ collection 1594  
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