Résumé des activités de recherche :

En poste à Brunoy depuis Septembre 2012, et après 3 années de post-doctorat passées dans l’unité, j’étudie aujourd’hui l’impact d’interventions nutritionnelles sur le métabolisme énergétique et les fonctions cognitives et comportementales chez un primate non-humain, le Microcèbe (Microcebus murinus). Utilisant différentes interventions nutritionnelles (restriction calorique modérée chronique, supplémentation en resvératrol et supplémentation en acides gras oméga-3), j’ai pu montrer leur influence sur les paramètres cognitifs et comportementaux. Parmi ces paramètres, je m’intéresse aux capacités mnésiques (mémoire spatiale de référence et mémoire émotionnelle en particulier), à l’activité locomotrice spontanée ou encore aux rythmes circadiens, notamment à travers le suivi des rythmes veille-sommeil par électroencéphalographie au cours du vieillissement.

L’ensemble de ces travaux me permet d’approfondir l’étude des liens entre nutrition, métabolisme énergétique, vieillissement et cognition. Outre le suivi des paramètres cognitifs et comportementaux, j’étudie également l’impact de la nutrition sur les rythmes biologiques, un paramètre décisif dans les processus de vieillissement. L’ensemble des mes travaux de recherches axé sur le contrôle central des fonctions cognitives et sur les mécanismes d’adaptation à des challenges énergétiques ou nutritionnels, s’inscrivent ainsi dans la thématique originale des neurosciences nutritionnelles

Summary of research activities

Based in Brunoy since September 2012 (after three years of post-doctoral fellowship in the laboratory), I am now studying the impact of nutritional interventions on energy metabolism on cognitive and behavioral functions in non-human primate, the grey mouse lemur (Microcebus murinus). Using various nutritional interventions (calorie restriction, resveratrol supplementation and supplementation with omega-3 fatty acids), I am studying their influence on cognitive and behavioral parameters. Among these parameters, I am interested in memory abilities (spatial memory and emotional memory reference), spontaneous locomotor activityor and circadian rhythms, including the monitoring of sleep-wake rhythms by electroencephalography during aging.

This work allows me to further explore the links between nutrition, energy metabolism, aging and cognition. In addition to tracking cognitive and behavioral parameters, I aam lso studying the impact of nutrition on biological rhythms, a key parameter in the aging process. All my research enters in the original field of Nutritional Neuroscience.

 

Publications :

 

Articles dans des revues internationales avec comité de lecture

 

1. (2015) Biggar KK, Wu CW, Tessier SN, Zhang J, Pifferi F, Perret M, Storey KB. Primate Torpor: Regulation of Stress-activated Protein Kinases During Daily Torpor in the Gray Mouse Lemur, Microcebus murinus. Genomics Proteomics Bioinformatics. Apr;13(2):81-90

 

2. (2015) Biggar KK, Wu CW, Tessier SN, Zhang J, Pifferi F, Perret M, Storey KB. Modulation of Gene Expression in Key Survival Pathways During Daily Torpor in the Gray Mouse Lemur, Microcebus murinus. Genomics Proteomics Bioinformatics. Apr;13(2):111-8.

 

3. (2015) Zhang J, Tessier SN, Biggar KK, Wu CW, Pifferi F, Perret M, Storey KB. Regulation of Torpor in the Gray Mouse Lemur: Transcriptional and Translational Controls and Role of AMPK Signaling. Genomics Proteomics Bioinformatics. Apr;13(2):103-10.

 

4. (2015) Tessier SN, Katzenback BA, Pifferi F, Perret M, Storey KB. Cytokine and Antioxidant Regulation in the Intestine of the Gray Mouse Lemur (Microcebus murinus) During Torpor. Genomics Proteomics Bioinformatics. Apr;13(2):127-35.

 

5. (2015) Tessier SN, Zhang J, Biggar KK, Wu CW, Pifferi F, Perret M, Storey KB. Regulation of the PI3K/AKT Pathway and Fuel Utilization During Primate Torpor in the Gray Mouse Lemur, Microcebus murinus. Genomics Proteomics Bioinformatics. Apr;13(2):91-102.

 

6. (2015) Wu CW, Biggar KK, Zhang J, Tessier SN, Pifferi F, Perret M, Storey KB. Induction of Antioxidant and Heat Shock Protein Responses During Torpor in the Gray Mouse Lemur, Microcebus murinus. Genomics Proteomics Bioinformatics. Apr;13(2):119-26.

 

7. (2015) Pifferi F, Dorieux O, Castellano CA, Croteau E, Masson M, Guillermier M, Van Camp N, Guesnet P, Alessandri JM, Cunnane S, Dhenain M, Aujard F. Long-chain n-3 PUFAs from fish oil enhance resting state brain glucose utilization and reduce anxiety in an adult nonhuman primate, the grey mouse lemur. J Lipid Res. Aug;56(8):1511-8.

 

8. (2014) Vuarin P, Henry PY, Guesnet P, Alessandri JM, Aujard F, Perret M, Pifferi F. Shallow hypothermia depends on the level of fatty acid unsaturation in adipose and liver tissues in a tropical heterothermic primate. J Therm Biol. Jul;43:81-8.

 

9. (2014) Tarragon E, Lopez D, Estrada C, Gonzalez-Cuello A, Ros CM, Lamberty Y, Pifferi F, Cella M, Canovi M, Guiso G, Gobbi M, Fernández-Villalba E, Blin O, Bordet R, Richardson JC, Herrero MT. Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus. Neuropharmacology. Oct;85:206-14.

 

10. (2013) Colavito V, Fabene PF, Grassi-Zucconi G, Pifferi F, Lamberty Y, Bentivoglio M, Bertini G. Experimental sleep deprivation as a tool to test memory deficits in rodents. Front Syst Neurosci. 2013 Dec 13;7:106. eCollection. Review.

 

11. (2013) Deguil J, Ravasi L, Auffret A, Babiloni C, Bartres Faz D, Bragulat V, Cassé-Perrot C, Colavito V, Herrero Ezquerro MT, Lamberty Y, Lanteaume L, Pemberton D, Pifferi F, Richardson JC, Schenker E, Blin O, Tarragon E, Bordet R. Evaluation of symptomatic drug effects in Alzheimer’s disease: strategies for prediction of efficacy in humans. Drug Discov Today Technol. Sep;10(3):e329-42.

 

12. (2013) Pifferi F, Dal-Pan A, Languille S, Aujard F. Effects of resveratrol on daily rhythms of locomotor activity and body temperature in young and aged grey mouse lemurs. Oxid Med Cell Longev. 2013:187301.

 

13. (2013) Marchal J, Pifferi F, Aujard F. Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span. Ann N Y Acad Sci. Jul;1290:67-73.

 

14. (2013) Rahman A, Languille S, Lamberty Y, Babiloni C, Perret M, Bordet R, Blin OJ, Jacob T, Auffret A, Schenker E, Richardson J, Pifferi F*, Aujard F*. Sleep deprivation impairs spatial retrieval but not spatial learning in the non-human primate grey mouse lemur. PLoS One. May 22;8(5):e64493. *Co-derniers auteurs

 

15. (2013) Tarragon E, Lopez D, Estrada C, Ana GC, Schenker E, Pifferi F, Bordet R, Richardson JC, Herrero MT.Octodon degus: a model for the cognitive impairment associated with Alzheimer’s disease. CNS Neurosci Ther. Sep;19(9):643-8.

 

16. (2013) Bonaconsa M, Colavito V, Pifferi F, Aujard F, Schenker E, Dix S, Grassi-Zucconi G, Bentivoglio M, Bertini G. Cell clocks and neuronal networks: neuron ticking and synchronization in aging and aging-related neurodegenerative disease. Curr Alzheimer Res. Jul;10(6):597-608.

 

17. (2012) Languille S, Aujard F, Pifferi F. Effect of dietary fish oil supplementation on the exploratory activity, emotional status and spatial memory of the aged mouse lemur, a non-human primate. Behav Brain Res. Dec 1;235(2):280-6.

 

18. (2012) Babiloni C, Infarinato F, Aujard F, Bastlund JF, Bentivoglio M, Bertini G, Del Percio C, Fabene PF, Forloni G, Herrero Ezquerro MT, Noè FM, Pifferi F, Ros-Bernal F, Christensen DZ, Dix S, Richardson JC, Lamberty Y, Drinkenburg W, Rossini PM. Effects of pharmacological agents, sleep deprivation, hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: Towards translational challenge models for drug discovery in Alzheimer’s disease. Clin Neurophysiol. Oct 4.

 

19. (2012) Marchal J, Blanc S, Epelbaum J, Aujard F, Pifferi F. Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus.

PLoS One.;7(3):e34289.

 

20. (2012) Pifferi F, Perret M, Guesnet P, Aujard F, Alessandri JM. Fatty Acid Composition of the Brain, Retina, Liver and Adipose Tissue of the Grey Mouse Lemur (Microcebus murinus, Primate). Lipids. Jun 10.

 

21. (2012) Pifferi F, Rhaman A, Languille S, Auffret A, Babiloni C, Blin O, Lamberty Y, Richardson J.C., Aujard F. The sleep-wake cycle in the non-human primate grey mouse lemur (Microcebus murinus): effects of dietary resveratrol supplementation. Chronobiology International.

 

22. (2012) Languille S, Blanc S, Blin O, Canale CI, Dal-Pan A, Devau G, Dhenain M, Dorieux O, Epelbaum J, Gomez D, Hardy I, Henry PY, Irving EA, Marchal J, Mestre-Francés N, Perret M, Picq JL, Pifferi F, Rahman A, Schenker E, Terrien J, Théry M, Verdier JM, Aujard F. The grey mouse lemur: A non-human primate model for ageing studies. Ageing Research Reviews. 11(1):150-62.

 

23. (2011) Vinot N, Jouin M, Lhomme-Duchadeuil A, Guesnet P, Alessandri JM, Aujard F, Pifferi F.

Omega-3 Fatty acids from fish oil lower anxiety, improve cognitive functions and reduce spontaneous locomotor activity in a non-human primate. PLoS One. 7;6(6):e20491.

 

24. (2011) Pifferi F, Dal-Pan A, Menaker M, Aujard F.

Resveratrol dietary supplementation shortens the free-running circadian period and decreases body temperature in a prosimian primate. Journal of Biological Rhythms. 26(3):271-5.

 

25. (2011) Dal-Pan A*, Pifferi F*, Marchal J, Picq JL, Aujard F.

Cognitive performances are selectively enhanced under chronic caloric restriction and resveratrol supplementation in a primate. Plos One. 31;6(1):e16581. *Co-premiers auteurs

 

26. (2011) Pifferi F, Tremblay S, Fortier M, Tremblay-Mercier J, Croteau E, Bentourkia M, Lecomte R, Cunnane S.C. Mild ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: A double tracer PET study in rats. Nutritional Neuroscience. 14(2):51-8.

 

27. (2011) Nugent S, Croteau E, Pifferi F, Fortier M, Tremblay S, Turcotte E and Cunnane SC.

Brain and systemic glucose metabolism in the healthy elderly following a fish oil supplementation. Prostaglandins Leukot Essent Fatty Acids. Nov;85(5):287

 

28. (2011) Cunnane SC, Nugent S, Roy M, Begdouri, Courchesne-Loyer A, Croteau E, Tremblay S, Pifferi F, Bocti C, Paquet N, Bentourkia M, Barberger-Gateau P,  Fulop T, and Rapoport SI.

Brain fuel metabolism, aging and Alzheimer’s disease. Nutrition. 27(1):3-20.

 

29. (2010) Dal-Pan A, Terrien J, Pifferi F, Botalla R, Hardy I, Marchal J, Zahariev A, Chery I, Zizzari P, Perret M, Picq JL, Epelbaum J, Blanc S, Aujard F.

Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinus. Age (Dordr). 33(1):15-31.

 

30. (2010) Pifferi F, Jouin M, Alessandri JM, Roux F, Perrière N, Langelier B, Lavialle M, Cunnane S, Guesnet P.

n-3 long-chain fatty acids and regulation of glucose transport in two models of rat brain endothelial cells. Neurochem Int. 56(5):703-10.

 

31. (2010) Croteau E, Lavallée E, Labbe SM, Hubert L, Pifferi F, Rousseau JA, Cunnane SC, Carpentier AC, Lecomte R, Bénard F.

Image-derived input function in dynamic human PET/CT: methodology and validation with (11)C-acetate and (18)F-fluorothioheptadecanoic acid in muscle and (18)F-fluorodeoxyglucose in brain. Eur J Nucl Med Mol Imaging. 37(8):1539-50.

 

32. (2010) Fortier M, Tremblay-Mercier J, Plourde M, Chouinard-Watkins R, Vandal M, Pifferi F, Freemantle E, Cunnane SC.

Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: higher fish intake or aging-related change in n-3 fatty acid metabolism? Prostaglandins Leukot Essent Fatty Acids. 82(4-6):277-80.

 

33. (2009) Cunnane SC, Plourde M, Pifferi F, Bégin M, Féart C, Barberger-Gateau P.

Fish, docosahexaenoic acid and Alzheimer’s disease. Prog Lipid Res. 48(5):239-56.

 

34. (2009) Bentourkia M, Tremblay S, Pifferi F, Rousseau J, Lecomte R, Cunnane S.

PET study of 11C-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis. Am J physiol Endocrinol Metab. 296(4):E796-801.

 

35. (2009) Plourde M, Tremblay-Mercier J, Fortier M, Pifferi F, Cunnane SC.

Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly. Nutrition. 25(3):289-94.

 

36. (2008) Pifferi F, Tremblay S, Plourde M, Tremblay-Mercier J, Bentourkia M, Cunnane SC.

Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate. Epilepsia. 49 Suppl 8:76-9.

 

37. (2007) Pifferi F, Jouin M, Alessandri JM, Haedke U, Roux F, Perrière N, Denis I, Lavialle M, Guesnet P.

n-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrier. Prostaglandins Leukot Essent Fatty Acids. (5-6):279-86.

 

38. (2007) Alessandri JM, Langelier B, Perruchot MH, Extier A, Pifferi F, Jouin M, Delpal S, Lavialle M, Guesnet P.

Conversion of n-3 polyunsaturated fatty acids (PUFAs) and incorporation of docosahexaenoic acid (DHA) in cultured neural cells. Oléagineux, Corps Gras, Lipides. 14, 148-54

 

39. (2007) Plourde M, Fortier M, Vandal M, Tremblay-Mercier J, Freemantle E, Bégin M, Pifferi F, Cunnane SC.

Unresolved issues in the link between docosahexaenoic acid and Alzheimer’s disease. Prostaglandins Leukot Essent Fatty Acids. 77:301-8.

 

40. (2005) Pifferi F, Roux F, Langelier B, Alessandri JM, Vancassel S, Jouin M, Lavialle M, Guesnet P.

(n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats. J Nutr. 135:2241-6.

 

41. (2005) Vancassel S, Aid S, Pifferi F, Morice E, Nosten-Bertrand M, Chalon S, Lavialle M.

Cerebral asymmetry and behavioral lateralization in rats chronically lacking n-3 polyunsaturated fatty acids. Biol Psychiatry. 15;58:805-11.

 

2 Articles dans des revues nationales avec comité de lecture

Pifferi F. Les acides gras omega-3 affectent différemment le comportement et la cognition chez un primate non-humain jeune ou âgé, le Microcèbe (Microcebus murinus). Oléagineux, Corps Gras, Lipides. 21(1). Publié en ligne : 22 Janvier 2014

(2011) Pifferi F, Aujard F. Growing old... in rhythm/Vieillir en rythmes. Biofutur. 325:46-49.

(2007) Lavialle M, Champeil-Potokar G, Denis I, Guesnet P, Pifferi F, Vancassel S. Le DHA dans la neurotransmission. Oléagineux, Corps Gras, Lipides. 14 :11-5

(2005) Guesnet P, Alessandri JM, Astorg P, Pifferi F, Lavialle M. Les rôles physiologiques majeurs exercés par les acides gras polyinsaturés (AGPI) Oléagineux, Corps Gras, Lipides. 12 : 333-43

 

3 Livres ou chapitres de livres

 (2010) Bégin M.E, Plourde M, Pifferi F and Cunnane S.C. Are fish and docosahexaenoic acid linked to lower risk of cognitive decline and Alzheimer’s disease? Recent Advances on Nutrition and the Prevention of Alzheimer’s Disease. Ed. Transworld Research Network.

 

(2009) Bégin M.E, Plourde M, Pifferi F and Cunnane S.C. What is the link between docosahexaenoic acid, cognitive impairment, and Alsheimer’s disease in the elderly? Fat detection. Taste, Texture, and Post-injestive effects. Ed. Frontiers in Neuroscience.

 

(2008) Alessandri J.M, Astorg P, Chardigny J.M, Pifferi F, Lavialle M et Guesnet P. Acides gras polyinsaturés (AGPI) - Structure, fonctions biologiques, apports nutritionnels recommandés et principales sources alimentaires. Aliments fonctionnels. Ed. Lavoisier.

 
 4 Articles dans des conférences internationales avec comité de lecture

 [37] (2007) Pifferi F, Jouin M, Roux F, Perrière N, Alessandri J-M, Lavialle M, Guesnet P. Omega-3 fatty acids and brain energy metabolism: Impact on the expression of glucose transporters and glucose transport activity in endothelial cells in culture. Oléagineux, Corps Gras, Lipides. 14(3):235 (% de sélection inconnu)

 

5 Conférences invitées dans des congrès nationaux ou internationaux

 

 Conférencier invité « Les Lundi de St Antoine » (UMPC-Hôpital St-Antoine, Paris, 21/01/2013). Pifferi F, Aujard F. Stratégies nutritionelles anti-vieillissement chez un primate non-humain, le Microcèbe

 Conférencier invité du Forum PILEJE 2012 (Institut Pasteur, Paris, Mars 2012). Pifferi F. Impact du resveratrol sur le vieillissement chez un primate non-humain, le Microcèbe.

 Conférencier invité de la réunion Mouse Lemur Genetics and Genomics:  Emerging Opportunities (Washington, D.C. Howard Hugues Medical Institute, 22-24 Juin 2011) : Pifferi F. The grey mouse lemur colony of Brunoy: a tool for pluridisciplinary research.

 Conférencier invité de la 7ème journée scientifique annuelle du Réseau Québécois de Recherche sur le Vieillissement, 27 novembre 2009, (Québec, QC, Canada) : Pifferi F, Aujard F. Le microcèbe, un primate prosimien, comme modèle du vieillissement.

 Conférencier invité du Centre de Recherche Clinique de l’Université de Sherbrooke, 30 Novembre 2009 (Sherbrooke, QC, Canada) : F. Pifferi, S.Tremblay, M. Fortier, J. Tremblay-Mercier, E. Croteau, M. Bentourkia, R. Lecomte, S.C. Cunnane. Effet d’une diète cétogène sur la captation cérébrale des corps cétoniques et du glucose, chez le rat

 

Conférencier invité  au 7ème FACS (Fatty Acids and Cell Signaling) Meeting / INRA (Institut National de la Recherche Agronomique) Workshop (Sept 28 – 30, 2005, Paris, France) : Pifferi F, Jouin M, Alessandri JM, Roux F, Perrière N, Lavialle M, Guesnet P. Omega-3 fatty acids and brain energy supply: impact on glucose transport

 

6 Posters, communications orales dans des conférences nat & int.

 

Posters dans des conférences nationales et internationales

 

Society for Neuroscience 2013 (New Orleans). The effect of donepezil and memantine on impaired spatial memory performances in a non-human primate, the grey mouse lemur

 

Alzheimer Assocciation International Congress 2013 (Boston).

(3 présentations affichées):

Use of sleep deprivation as a translatable challenge to induce cognitive impairment in rodents and non-human primates: An IMI PHARMACOG initiative. A Rahman, E Tarragon-Cros, MT Herrero, G Bertini, M Pellitteri, P Fabene, V Colavito, M Bentivoglio, Y Lamberty, C Babiloni, R Bordet, A Auffret, E Schenker, JC Richardson, F Aujard, F Pifferi

 

Donepezil prevented the cognitive impairment induced by sleep deprivation in a non-human primate, the grey mouse lemur. Rahman A, Pifferi F, Lamberty Y, Schenker E, Aujard F

 

Memantine prevents the reference and working memory impairment caused by sleep deprivation in Octodon degus, a potential animal model for Alzheimer’s disease. Tarragon E , Lopez D, Estrada C, Ros-Bernal F, González-Cuello A, Lamberty Y, Pifferi F, Bordet R, Richardson JC, Herrero MT

 

8th Göttinger Freilandtag (Göttingen, Germany, 2011):

“Cognitive performances are improved in response to a chronic nutritional constraint in middle-aged non-human primates, Microcebus murinus”. Marchal J, Dal-Pan A, Lelli L, Pifferi F, Picq JL, Aujard F

 

Congrès annuel de la Society for Neuroscience (Washington, USA, 12-16 Novembre 2011)

(2 présentations affichées):

Sleep changes during aging: electroencephalography (EEG) study in a non-human primate.  Pifferi F, Rhaman A, Languille S, Blin O, Irving E, Babiloni C, Bentivoglio M, Aujard F

 

Induction of cognitive impairment in adult mouse lemur, a potential non-human primate model of Alzheimer’s disease. Rhaman A, Languille S, Pifferi F, Blin O, Irving E, Lamberty Y, Schenker E, Lestage P, Aujard F

 

5th IPHC Polyphenols and Health (Sitges, Barcelona, Spain, 2011):

"Polyphenol enriched nutrition as an anti-aging strategy in a primate: impact of a chronic oral intake of resveratrol on aging biomarkers and longevity" Marchal J, Dal-pan A, Pifferi F, Blanc S, Epelbaum J, Aujard F

 

Journées Fats And Brain (Paris, Mars 2011) :

Omega-3 fatty acids from fish oil and cognitive functions in a primate: Microcebus murinus. Vinot N, Jouin M, Lallemand MS, Linard A, Alessandri JM, Guesnet P, Aujard F, Pifferi F.

 

Congrès BRAIN 2011 (Congrès de l’International Society for Cerebral Blood Flow and Metabolism) (Barcelone, 24-28 Mai 2011) (3 présentations affichées):

Nugent S, Croteau E, Pifferi F, Fortier M, Turcotte E, and Cunnane SC. Different units for expressing PET data have a significant impact on interpreting possible aging-related differences in brain glucose uptake.

 

Nugent S, Croteau E, Pifferi F, Fortier M, Turcotte E, and Cunnane SC. Plasma insulin and triglyceride levels correlate inversely with the cerebral metabolic rate of glucose in healthy humans.

 

Tremblay S, Pifferi F, Fortier M, Tremblay-Mercier J, Croteau E, Lecomte R, Cunnane S.C. Cerebral uptake of ketone bodies for a ketogenic diet in rats by PET studies with [11C]Acetoacetate tracer.

 

7ème journée scientifique annuelle  du Réseau Québécois de Recherche sur le Vieillissement (27 novembre 2009, Québec, QC, Canada):

Nugent S, Croteau E, Pifferi F, Fortier M, Bentourkia M, Turcotte E, Cunnane S. Plasma glucose and triglyceride are inversely associated with brain glucose uptake.

 

World molecular imaging congress 23-26sept 2009 (Montréal, QC, Canada):

Tremblay S, Pifferi F, Fortier M, Tremblay-Mercier J, Croteau E, Beaudoin J.-F, Bentourkia M, Lecomte R, Cunnane S.C. Influence of mild, experimental ketonemia on cerebral metabolism in rats: A PET study with [11C]acetoacetate and [18F]fluorodeoxyglucose

 

11ème congrès de l’European Biological Rhythms Society (22-28 Août 2009) (Strasbourg, France):

Pifferi F*, Dal-Pan A, Terrien J, Botalla R, Hardy I, Aujard F. Impact of calorie restriction or a mimetic (resveratrol) on daily rhythms of locomotor activity in a non-human primate

                                  

19ème congrès de l’IAGG (International Association of Gerontology and Geriatrics) 5-9 Juillet 2009 (Paris, France):

Cunnane SC, Bentourkia M, Tremblay S, Croteau E, Sarrhini O, Pifferi F, Fortier M, Filteau C.  PET imaging of brain fuel uptake: moving towards understandind the link between cognition and brain metabolism in the elderly

 

4ème reunion de l’International Academy on Nutrition and Age Related Diseases (5 Juillet 2009) (Paris, France):

Omega-3 fatty acid supplementation does not affect brain glucose uptake in the healthy aging: A PET study. Pifferi F*, Croteau E, Fortier M, Langevin C, Turcotte E, Cunnane S.

 

6ème journée scientifique du Centre de Recheche sur le Vieillissement de Sherbrooke (8 mai 2009, Orford, QC, Canada):

Tremblay S, Pifferi F, Authier S,    Fortier M, Tremblay-Mercier J, Ouellet R, Rodrigue S, Dubuc C, Dumulon V, Rousseau J, Beaudoin J.-F, Bergeron M, Archambault M, Bentourkia M,   Lecomte R, Bénard F, Cunnane S.C. Étude du métabolisme des cétones au cerveau grâce à la tomographie d’émission de positrons: études animales.

 

World molecular imaging congress 2008 (Nice, France):

Tremblay S, Pifferi F, Ouellet R, Authier S, Rodrigue S, Dubuc C, Dumulon V, Rousseau J, Beaudoin J-F, Bergeron M, Archambault M, Bentourkia M,  Lecomte R, Bénard F, Cunnane S.C. Carbon-11 Labeling of Ketone Bodies for PET Studies

 

8ème congrès ISSFAL (International Society for the Study of Fatty Acids and Lipids) (17-22 Mai 2008, Kansas City, Missouri):

Pifferi F*, Jouin M, Roux F, Perrière N, Alessandri J-M, Lavialle M, Cunnane SC & Guesnet P. Impact of polyunsaturated fatty acids on the expression of glucose transporters and glucose transport activity in rat brain endothelial cells. Prix de la meilleure communication affichée

 

8ème FACS meeting (Fatty Acids and Cell Signaling) (Juin 2007, Québec):

Pifferi F*, Jouin M, Headke U, Alessandri JM, Roux F, Perrière N, Lavialle M, Guesnet P. Impact of omega-3 fatty acids on glucose transport in cerebral endothelial cells and astrocytes

 

7ème congrès ISSFAL (International Society for the Study of Fatty Acids and Lipids) (23-28 Juillet 2006, Cairns, Australia):

Pifferi F*, Jouin M, Alessandri JM, Roux F, Perrière N, Lavialle M, Guesnet P. Impact of omega-6 and omega-3 fatty acid (FA) supplementation on membrane composition and glucose transport in two in vitro models of the blood-brain barrier, the rat brain endothelial cell primary culture (RBEC) and the cell line RBE4. (Présenté par Philippe Guesnet)

 

6ème Cerebral Vascular Biology International Conference, (25-29 Juin 2005, Münster, Germany) (2 communications affichées):

Pifferi F*, Jouin M, Lallemand M, Linard A, Lavialle M, Guesnet P. n-3 fatty acids deficiency: impact on glucose utilization and transport in blood-brain barrier endothelial cells and astrocytes.

Jouin M, Pifferi F*, Lallemand M, Linard A, Lavialle M, Guesnet P. Phospholipid incorporation of long chain polyunsaturated fatty acids in rat brain endothelial cells in primary culture.

 

Colloque DOC’J (Association des doctorants et stagiaires de l’INRA de Jouy en Josas) (Mai 2005, Jouy en Josas, France):

Pifferi F*, Guesnet P, Roux F, Langelier B, Alessandri JM, Lavialle M. n-3 deficient diet affects the expression of GLUT1 in endothelial cells and astrocytes.

 

6ème congrès ISSFAL (International Society for the Study of Fatty Acids and Lipids) (27 Juin – 1er Juillet 2004, Brighton, UK):

Pifferi F*, Guesnet P, Roux F, Langelier B, Alessandri JM, Lavialle M. n-3 deficient diet affects the expression of GLUT1 in endothelial cells and astrocytes. Prix de la meilleure communication affichée.

 

 

Communications orales dans des conférences nationales et internationales

 

Conférences PNRA 2012 (éditions ANR PNRA 2006-2007) :

Marchal J, Dal-Pan A, Pifferi F, Picq JL, Dhenain M, Epelbaum J, Blanc S, Aujard F. «Does the sirtuin pathway activation by dietary resveratrol supplementation mimic the calorie restriction effects on increased longevity in a non human primate?"

 

Congrès de la Société Francophone de Chronobiologie 2012 ( )

 

Congrès de la Société Francophone de Chronobiologie 2010 (8-10 Septembre 2010, La Colle sur Loup): Pifferi F, Dal-Pan A, Aujard F. Une supplémentation alimentaire en Resvératrol diminue la période endogène et la température corporelle chez un primate prosimien

 

8ème congrès ISSFAL (International Society for the Study of Fatty Acids and Lipids) (17-22 Mai 2008, Kansas City, Missouri) :

Vandal M, Pifferi F, Plourde M, freemantle E, Zhang Y, Tremblay-Mercier J, Fortier M, Bégin M, Brenna JT, and Cunnane SC. DHA metabolism in the healthy elderly.

 

9ème Réunion annuelle de la Société Québecoise de Lipidologie, Nutrition et Métabolisme (SQLNM) (1-3 Mai 2008, Laval, QC, Canada) :

Pifferi F, Jouin M, Roux F, Perrière N, Alessandri J-M, Lavialle M, Cunnane SC, Guesnet P. Impact des acides gras polyinsatures sur l’expression des transporteurs de glucose et leur activité dans les cellules endothéliales cérébrales, chez le rat. Prix de la meilleure présentation orale

 

Réunion annuelle du Club de la Barrière Hémato-encéphalique (Juin 2004, Paris, France) :

Pifferi F, Jouin M, Alessandri JM, Roux F, Perrière N, Lavialle M, Guesnet P. Acides Gras Polyinsaturés de la série n-3 et métabolisme énergétique cérébral

 

Publications