Activités:

Pour l’unité ou dans le cadre de collaborations externes et de la plateforme IBISA, je réalise des dosages biologiques par méthode ELISA pour des programmes de recherche sur différents modèles animaux (mélatonine, cortisol, créatinine, insuline, estradiol, testostérone, T3, T4...). Je mets aussi en oeuvre des techniques de biologie moléculaire ou histologiques.

Je suis également Assistante de Prévention.

 

Parcours:

- Décembre 1993 - janvier 2001 : Institut d’Embryologie Cellulaire et Moléculaire de Nogent-Sur-Marne (94).

- Février 2001 - Novembre 2013 : Institut Curie d’Orsay (91) Equipe "Développement normal et pathologique des mélanocytes"

- Décembre 2013 : Museum d’Histoire Naturelle UMR7179 (Brunoy-91)

 

 

Publications:

A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus.             

Yajima I, Colombo S, Puig I, Champeval D, Kumasaka M, Belloir E, Bonaventure J, Mark M, Yamamoto H, Taketo MM, Choquet P, Etchevers HC, Beermann F, Delmas V, Monassier L, Larue L. PLoS One. 2013;8(1):e53183. doi: 10.1371/journal.pone.0053183. Epub 2013 Jan 31. PMID: 23382837

 

Beta-catenin inhibits melanocyte migration but induces melanoma metastasis.

Gallagher SJ, Rambow F, Kumasaka M, Champeval D, Bellacosa A, Delmas V, Larue L. Oncogene. 2013 Apr 25;32(17):2230-8. doi: 10.1038/onc.2012.229. Epub 2012 Jun 4. PMID: 22665063

 

Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation.

Berlin I, Denat L, Steunou AL, Puig I, Champeval D, Colombo S, Roberts K, Bonvin E, Bourgeois Y, Davidson I, Delmas V, Nieto L, Goding CR, Larue L. Mol Cell Biol. 2012 Apr;32(7):1237-47. doi: 10.1128/MCB.06257-11. Epub 2012 Jan 30.PMID: 22290434

 

General strategy to analyse coat colour phenotypes in mice.

Berlin I, Luciani F, Gallagher SJ, Rambow F, Conde-Perez A, Colombo S, Champeval D, Delmas V, Larue L. Pigment Cell Melanoma Res. 2012 Jan;25(1):117-9. doi: 10.1111/j.1755-148X.2011.00912.x. Epub 2011 Nov 16. PMID: 22085368

 

General strategy to analyse melanoma in mice.

Gallagher SJ, Luciani F, Berlin I, Rambow F, Gros G, Champeval D, Delmas V, Larue L. Pigment Cell Melanoma Res. 2011 Oct;24(5):987-8. doi: 10.1111/j.1755-148X.2011.00907.x. Epub 2011 Sep 29. PMID: 21955491

 

Biological and mathematical modeling of melanocyte development.

Luciani F, Champeval D, Herbette A, Denat L, Aylaj B, Martinozzi S, Ballotti R, Kemler R, Goding CR, De Vuyst F, Larue L, Delmas V. Development. 2011 Sep;138(18):3943-54. doi: 10.1242/dev.067447. PMID: 21862558

 

Transcriptomic analysis of mouse embryonic skin cells reveals previously unreported genes expressed in melanoblasts.

Colombo S, Champeval D, Rambow F, Larue L. J Invest Dermatol. 2012 Jan;132(1):170-8. doi: 10.1038/jid.2011.252. Epub 2011 Aug 18. PMID: 21850021

 

Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction.

Puig I, Champeval D, De Santa Barbara P, Jaubert F, Lyonnet S, Larue L. J Clin Invest. 2009 Dec;119(12):3586-96. doi: 10.1172/JCI39929. Epub 2009 Nov 2. PMID: 19884655

 

Bypassing melanocyte senescence by beta-catenin: a novel way to promote melanoma.

Larue L, Luciani F, Kumasaka M, Champeval D, Demirkan N, Bonaventure J, Delmas V. Pathol Biol (Paris). 2009 Nov-Dec;57(7-8):543-7. doi: 10.1016/j.patbio.2008.11.003. Epub 2009 Feb 6. Review. PMID: 19201106

 

Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.

Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A. Dev Biol. 2009 Jan 1;325(1):225-37. doi: 10.1016/j.ydbio.2008.10.020. Epub 2008 Oct 29. PMID: 19000668

 

Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation.

Moore R, Champeval D, Denat L, Tan SS, Faure F, Julien-Grille S, Larue L. Oncogene. 2004 Sep 2;23(40):6726-35. PMID: 15273735

 

Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.

Goodall J, Martinozzi S, Dexter TJ, Champeval D, Carreira S, Larue L, Goding CR. Mol Cell Biol. 2004 Apr;24(7):2915-22. PMID: 15024079

 

Sacral neural crest cells colonise aganglionic hindgut in vivo but fail to compensate for lack of enteric ganglia.

Burns AJ, Champeval D, Le Douarin NM. Dev Biol. 2000 Mar 1;219(1):30-43. PMID: 10677253

 

Endothelin 3 selectively promotes survival and proliferation of neural crest-derived glial and melanocytic precursors in vitro.

Lahav R, Dupin E, Lecoin L, Glavieux C, Champeval D, Ziller C, Le Douarin NM. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14214-9. PMID: 9826680

 

The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo.

Nataf V, Grapin-Botton A, Champeval D, Amemiya A, Yanagisawa M, Le Douarin NM. Mech Dev. 1998 Jul;75(1-2):145-9. PMID: 9739130